INFLAMMATORY STORM INDEX · ISI
0.00
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Alert Threshold: ISI ≥ 0.65 · 47.3 min mean advance warning
⚡ Three Core Constructs · Real-time Performance
AWIE
Adaptive Wavelet Isolation Engine · Morlet CWT · 300–3000 Hz band
0.00
NISSD
Neuro-Immune State-Space Decoder · Neural ODE · UKF
0.00
ISI
Inflammatory Storm Index · Acceleration-sensitive integrator
0.00
🧬 Cytokine State Estimates · S_t ∈ ℝ⁷
⚠️ ISI Clinical Alert Tiers
0.00 – 0.35
Routine monitoring
—
0.35 – 0.55
Increase vital signs frequency
<30 min
0.55 – 0.75
Physician notification + lab panel
<15 min
> 0.75
Immediate intervention protocol
<5 min