Biomedical & Clinical AI Research Series
| Method | Accuracy / Alert | Advance Warning | AUROC | Limitation |
|---|---|---|---|---|
| SOFA Score (Sepsis-3) | 74.1% | 0 min (lagging) | 0.741 | Lagging indicator |
| NEWS2 + Lactate | 78.6% | <15 min | 0.793 | Lab latency |
| PCT + IL-6 panel | 83.2% | <30 min | 0.847 | 60–180 min draw |
| EHR-LSTM (Moor et al.) | 86.1% | ~3 hours | 0.871 | Retrospective |
| Wearable ECG sepsis | 78.0% | ~2 hours | 0.780 | Non-specific |
| Vagus-Decipher AI | 91.4% | 47.3 min | 0.963 | Requires vagal ENG interface |
| Configuration | Accuracy | Lead Time | AUROC | FPR |
|---|---|---|---|---|
| No AWIE (raw signal) | 67.3% | 28.1 min | 0.821 | 12.4% |
| AWIE only (no beamformer) | 78.9% | 36.4 min | 0.882 | 8.7% |
| Full AWIE (no NISSD, rate threshold) | 81.2% | 38.9 min | 0.901 | 6.9% |
| AWIE + NISSD (no physics constraint) | 86.4% | 42.1 min | 0.931 | 5.8% |
| AWIE + NISSD + physics (no ISI integrator) | 88.7% | 44.8 min | 0.944 | 4.6% |
| Vagus-Decipher AI v1.0.0 (Full) | 91.4% | 47.3 min | 0.963 | 3.2% |
| Phase | Condition | Behavior | Resilience |
|---|---|---|---|
| Phase I — Stable | S(t) ≫ θ_c | Converges to attractor | Resilient to moderate shocks |
| Phase II — Critical | S(t) ≈ θ_c | Sensitivity diverges; EWS rise | Fragile; elevated collapse risk |
| Phase III — Collapse | S(t) < θ_c | Transition to new attractor | Recovery requires strong shocks |